Portable Microfluidic Chip for Cell Separation and Visual Quantification of Heavy Metal Ions and Biomarkers
National Natural Science Foundation of China, Youth Science Foundation Project (Category C), Biomimetic Gating and Cascade Effect-Based Localized Drug Delivery System for Tumor Treatment, CNY: 300,000, 2026.01-2028.12, Principal Investigator
Start-up Research Grant, Portable Microfluidic Biosensors, CNY: 800,000, Principal Investigator
Zhongyuan Talent Plan (Overseas Postdoctoral Researchers) – Young Talent Project, Department of Henan Human Resources and Social Security of Henan Province
期刊论文/Journal Papers
(#: 共同作者/equal contribution; *: 通讯作者/corresponding author)
1.Gaobo Wang, Natsuho Moriyama, Soichiro Tottori, Matsuhiko Nishizawa*. Recent advances in iontophoresis-assisted microneedle devices for transdermal biosensing and drug delivery.Materials Today Bio31, 101504, 2025
2.Gaobo Wang, Yuina Abe, Soichiro Tottori, Shuto Osaki, Matsuhiko Nishizawa*. Porous Microneedles: Transdermal Salt Bridge for Biomedical Device Engineering.Current Opinion in Biomedical Engineering100593, 2025
3.Gaobo Wang, Chenxing Li, Yunhao Sun, Soichiro Tottori, Matsuhiko Nishizawa*. Tunable electroosmotic pumping via electrical double layer charging.ACS Materials Letters7, 3, 741-745, 2025
4.Gaobo Wang#, Yuyue Zhang#, Hoi Kwan Kwong#, Mengjia Zheng, Jianpeng Wu, Chenyu Cui, Kannie W. Y. Chan, Chenjie Xu*, and Ting-Hsuan Chen*. On-site melanoma diagnosis utilizing a swellable microneedle-assisted skin interstitial fluid sampling and a microfluidic particle dam for visual quantification of S100A1.Advanced Science2306188, 2024
5.Gaobo Wang, Kosuke Kato, Sae Ichinose, Daisuke Inoue, Airi Kobayashi, Hitoshi Terui, Soichiro Tottori, Makoto Kanzaki, Matsuhiko Nishizawa*. Bilaterally aligned electroosmotic flow generated by porous microneedle device for dual-mode delivery.Advanced Healthcare Materials2401181, 2024
6.Gaobo Wang, Kosuke Kato, Izuru Aoki, Sae Ichinose, Daisuke Inoue, Soichiro Tottori and Matsuhiko Nishizawa*. Transdermal drug delivery using a porous microneedle device driven by a hydrogel electroosmotic pump.Journal of Materials Chemistry B12, 1490-1494, 2024
7.Gaobo Wang#, Jiaheng Li#, Siying Wu, Tianyi Jiang, and Ting-Hsuan Chen*. A fully integrated, ready-to-use distance-based chemosensor for visual quantification of multiple heavy metal ions.Analytical Chemistry94, 46, 15925–15929, 2022
8.Gaobo Wang, Minghui Wu, Lok Ting Chu, Ting-Hsuan Chen*. Portable microfluidic device with thermometer-like display for real-time visual quantitation of Cadmium(ii) contamination in drinking water.Analytica Chimica Acta1160, 338444. 2022
9.Gaobo Wang#, Lok Ting Chu#, Hogi Hartanto, William Budi Utomo, Reynard Aaron Pravasta, and Ting-Hsuan Chen*. Microfluidic particle dam for visual and quantitative detection of lead ions.ACS Sensors5, 19–23, 2020
10. Minghui Wu#,Gaobo Wang#, Lok Ting Chu, Hanjin Huang, Ting-Hsuan Chen*. Cascade-amplified microfluidic particle accumulation enabling quantification of lead ions through visual inspection.Sensors and Actuators B: Chemical324, 128727, 2020
11. Hamidreza Shirinkami#,Gaobo Wang#, Jinhyeok Park, Joonhyang Ahn, Yeonho Choi*, Honggu Chun*. Red blood cell and white blood cell separation using a lateral-dimension scalable microchip based on hydraulic jump and sedimentation.Sensors and Actuators B: Chemical307, 127412, 2020
12. Minghui Wu#, Siying Wu#,Gaobo Wang, Wengang Liu, Lok Ting Chu, Tianyi Jiang, Hoi Kwan Kwong, Hiu Lam Chow, Iris Wai Sum Li, Ting-Hsuan Chen*. Microfluidic particle dam for direct visualization of SARS-CoV-2 antibody levels in COVID-19 vaccinees.Science Advances8(22), eabn6064, 2021
13. Daigo Terutsuki, Sho Miyazawa, Junya Takagi, Akihiro Yamada, Yunhao Sun, Hiroya Abe,Gaobo Wang, Matsuhiko Nishizawa*. Spatiotemporally controllable chemical delivery utilizing electroosmosis flow generated in combination of anionic and cationic hydrogel.Advanced Functional Materials34, 2304946, 2024
14. Jiaheng Li, Lok Ting Chu, Hogi Hartanto, Guihuan Guo, Lu Liu, Jianpeng Wu, Minghui Wu, Chenyu Cui,Gaobo Wang, Wengang Liu, Hoi Kwan Kwong, Siying Wu, Ting-Hsuan Chen*. Microfluidic particle counter visualizing mucosal antibodies against SARS-CoV-2 in the upper respiratory tract for rapid evaluation of immune protection.Lab Chip24, 2658-2668, 2024
15. Minghui Wu, Hogi Hartanto, Siying Wu, Tianyi Jiang,Gaobo Wang, Ting-Hsuan Chen*. Visualizing alpha-fetoprotein level in undiluted serum based on microfluidic particle accumulation.Sensors and Actuators B: Chemical390, 133963. 2023
16. Tianyi Jiang,Gaobo Wangand Ting-Hsuan Chen*. Microfluidic particle accumulation for visual quantitation of copper ions.Microchimica Acta188, 176, 2021
17. Siying Wu, Minghui Wu,Gaobo Wang, Ting-Hsuan Chen*. Visual quantitation of silver contamination in fresh water via accumulative length of microparticles in capillary-driven microfluidic devices.Talanta235, 122707, 2021
18. Soichiro Tottori, Sae Ichinose, Fumika Sakai, Reiji Segawa, Taiki Yokoyama,Gaobo Wangand Matsuhiko Nishizawa*. Quantitative evaluation of accelerated transdermal drug delivery by electroosmosis via frustoconical porous microneedles.Journal of Materials Chemistry B13, 5023-5026, 2025
会议报告/Conferences
1.Gaobo Wang, Hamidreza Shirinkami, Honggu Chun*. Leukocyte and Erythrocyte Sorting Microchip Using Hydraulic Jump Phenomenon. The Korean Biochip Society, Pyeongchang, South Korea, 16-18 May (2018)
2.Gaobo Wang, Lok Ting Chu, Hogi Hartanto, William Budi Utomo, Reynard Aaron Pravasta, and Ting-Hsuan Chen*. Microfluidic Particle Dam for Visual and Quantitative Detection of Lead Ions. The 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS), Congress Center Basel, Basel, Switzerland, 27-31 October (2019)
3.Gaobo Wang, Yuyue Zhang, Hoi Kwan Kwong, Mengjia Zheng, Jianpeng Wu, Chenyu Cui, Kannie W. Y. Chan, Chenjie Xu*, and Ting-Hsuan Chen*. On-site melanoma diagnosis utilizing a swellable microneedle-assisted skin interstitial fluid sampling and a microfluidic particle dam for visual quantification of S100A1. CHEMINAS48, Kumamoto, Japan, 6-8 November (2023)
4.汪高博. 基于多孔微针的经皮药物递送系统研究（口头报告）, “微系统与纳米工程（MINE）”学术年会，中国西安，Sep 21-23, 2024
5.汪高博. Microneedle for Localized Drug Delivery（Poster）, 第十届上海国际分析化学研讨会，中国上海，Nov 18-19, 2024
6.汪高博. 电渗流辅助下的智能可控局部给药器件研究（口头报告）, 中国微米纳米技术学会第十届青年科学家论坛，中国南京，May, 16-18 2025
7.汪高博. 微纳生物医学器件在精准诊断与治疗中的应用（口头报告）, 2025先进功能材料与器件学术研讨会，中国西安，June 27-29, 2025
8.汪高博. 基于距离读数的微流控诊断平台（口头报告），中国微米纳米技术学会第八届微流控技术应用创新论坛，中国广州，Aug 1-4, 2025
